Opening College Football Week 6 Odds, Spreads and Early Predictions

Penn State visits Iowa at 8 p.m. ET on Saturday. Iowa is a two-point favorite. Georgia plays at Auburn, Oklahoma plays against Oklahoma, Texas plays Texas and Mississippi plays Arkansas.

Penn State beat Indiana 24-0 on Saturday night. Sean Clifford threw for 178 yards and three touchdowns. Jahan Dotson caught a pair of touchdown passes and Brenton Strange added one. Jordan Stout added a 50-yard field goal in the fourth quarter. Iowa beat Maryland 51-7 on Friday night and forced seven turnovers.

Georgia is a 15-point favorite against Auburn. Georgia beat Arkansas 37-0 on Saturday. Auburn won in Baton Rogue for the first time since 1999. Bo Nix passed for a touchdown and ran for another. Auburn beat LSU 24-19 on the road. Bydarrius Knighten intercepted a pass on fourth down at the Auburn 39.

Cincinnati is a 28.5-point home favorite over Temple on Friday night. The public will jump on Cincinnati after their win at Notre Dame. Temple is 3-2, but its two losses have been to Power Five schools Rutgers and Boston College by a combined 72 points.