Penn State vs Purdue: Prediction, pick, spread, football game odds, live stream, watch online, TV channel

Penn State and Purdue are coming off different seasons in 2021. Purdue improved to 9-4 last season and went 6-3 in the Big Ten. Penn State went 7-6 in 2020 and 4-5 in conference play. The last meeting between the two teams was in 2019 when Penn state won 35-7 at Beaver Stadium.

Purdue has a lot to replace this season, but they have some solace in having Aidan O'Connell back as their starting quarterback. O'sConnell finished the season with 3,708 yards passing and 28 touchdowns.

Sean Clifford is the offensive coordinator at Penn State. He has a similar situation to Ryan Hilinski, who is entering 2022. Hilinksi threw for 314 yards to help Northwestern to an upset win over Nebraska.

Nick Singleton is a freshman running back for Penn State. The team has struggled to run the ball since the days of Saquon Barkley and Miles Sanders. Sington is talented and could be a big boost to the offense.

Penn State plays Purdue. The game is live on TV and online.

Penn State is favored by 3.5 points at home against Purdue. The game will be shown live on TV. SportsLine's computer model has returned almost $3,600 in profit over the past six-plus seasons. It has picked Penn State to win.