Purdue vs. Penn State prediction: College Football odds and picks today
![Purdue vs. Penn State prediction: College Football odds and picks today](/img/li/purdue-vs-penn-state-prediction-college-football-odds-and-picks-today-1.jpg)
Purdue and Penn State are playing in the first college football game of the season on Thursday. The Boilermakers are a 3-point favorite. Aidan O'Connell is the quarterback for Purdue. On defense, the Boilers lost two key players in George Karlaftis and Jaylan Alexander, but return nine starters from a unit that ranked 34th in scoring and 48th overall last season.
Penn State lost six of their last eight games in 2021. They play Purdue, who finished the season 9-4.