Purdue vs. Syracuse odds, prediction, line, spread: 2022 Week 3 college football picks from model on 50-41 run

Purdue Boilermakers (1-1) travel to JWA Wireless Dome to play Syracuse Orange (2-0) in a non-conference game on Saturday. Purdue crushed Indiana State 56- 0 last week. Syracuse has won two straight games, including last weekend's 48-14 victory over UConn. The teams have only met once before, with Purdue winning 51-7 in 2004. SportsLine Projection Model simulates every FBS college football game 10,000 times. It has generated a profit of almost $3,400 for $100 players on its top-rated collegeFootball picks against the spread since 2021.

Purdue vs. Syracuse is a college football game on Saturday. The money line is Purdue +105, the spread is 1.5, and the over-under is 60 points. Purdue is 4-1 ATS in their last five games overall and 6-0 AET in the last seven home games. SportsLine's computer model has picked Purdue.

Purdue vs. Syracuse money line is Boilermakers +105, Orange -125. Purdue is 4-1 ATS in their last 5 games overall and 6-2 AET in last 7 home games.

Syracuse is the favorite to cover against Purdue. Junior quarterback Garrett Shrader is an athletic playmaker who uses his legs to pick up easy yards. Sophomore running back Sean Tucker is a dual-threat coming out of the backfield.

Purdue is favored to cover against Syracuse. Aidan O'Connell was named to the 2021 All-Big Ten team last season. Charlie Jones is leading the Big Ten in catches (21), receiving yards (286) and receiving touchdowns (4).

SportsLine's model is leaning Under on the total. It projects the teams to combine for 50 points. One side of the spread hits in well over 50% of simulations.