Syracuse football: Orange start the season as home underdogs to Louisville Cardinals
Syracuse Orange open their 2022 season at home against the Louisville Cardinals. The line on the game opened with the Orange +3.5 and is currently sitting at Syracuse +4. Louisville is bringing Malik Cunningham to the match. This is the fifteenth meeting between the schools since 1985. Since Syracuse joined the ACC in 2013, the series is 7-1 in favor of Louisville.
