Top 5 MLB Player Prop Bets Odds, Picks & Predictions: Thursday (9/22)

The Top 5 MLB Player Prop Bets Odds, Picks and Predictions for Thursday (9/22) are:

Shane Bieber and the Guardians take on the White Sox in a pivotal series regarding the A.L. Central Division. Cleveland has a six-game lead over the Chicago White Sox. Bieber is 2-2 against Chicago this season and has only allowed more than one earned once in one of those starts.

Hunter Greene has gone over the 16.5 outs in three straight starts. He has only managed to do that once in his previous seven starts before tonight. The Milwaukee Brewers are batting .296 and have an OBS of 1.173 and SLG% of .796 against Greene. In his three starts against the Brewers this season, he has failed to top 16:5 Outs.

Jose Berrios has a strikeout rate of 12.1% in his last four starts. He has faced Tampa Bay Rays twice this season and failed to strike out more than four batters in both of them.

George Kirby is 7-4 with a 2.98 ERA for the Seattle Mariners this season. Seattle is a heavy favorite, -226 on the moneyline, but Kirby's +120 to record the win. In three starts against the Athletics, Kirby has a record of 1-0 with 2-50 ERA.

Austin Riley is one of the best against left-handed pitchers. Riley slashes .336/.423/.709 with an ISO of .373 and a wOBA of .472 against them in 2022.