Twins vs. Guardians odds, prediction, line: 2022 MLB picks, Monday, Sept. 19 best bets from proven model

Twins and Guardians are playing a game on Monday at 1:10 p.m. ET. The Twins are six games behind the Cleveland Guardians in the American League Central Division. Cleveland is a –120 favorite on the money line. SportsLine's proven computer model simulates every MLB game 10,000 times. It is 316-272 on top-rated money-line picks since the start of the 2021 season.

SportsLine's advanced model has selected its MLB picks for Twins vs. Guardians. Twins are 35-16 in their last 51 Monday games. The Guardians are 8-2 in the last 10 games and are favored by 1.5 runs.

Twins vs. Guardians is Monday, Sept. 19. Twins are 35-16 in their last 51 Monday games. The Guardians are 8-2 in the last 10 games and are favored by 7 runs.

Cleveland is expected to send right-hander Cal Quantrill to the mound. Quantill has been hot, winning eight of his last eight decisions over a span of 13 games. Amed Rosario is batting .370 against Minnesota in 18 games in 2022.

Sonny Gray will start for Minnesota against Guardians. Gray has a 2.83 ERA this season. Carlos Correa has been on a tear with hits in 13 of his past 15 games. In his last seven games against Cleveland, he is 12-for-32 with one homer and four RBI.

SportsLine's model is leaning Over on the total and projects 7.6 combined runs. One side of the money line has all the value.