White Sox vs. Guardians odds, line, prediction: 2022 MLB picks, April 20 best bets from proven computer model

Cleveland Guardians were swept by San Francisco over the weekend. They play the Chicago White Sox on Wednesday afternoon in the first game of a doubleheader. Chicago had won six games in a seven-game stretch before losing to Tampa Bay on Sunday. The White Sox have won four of the last six meetings between these teams.

Guardians vs. White Sox is a game on April 20th. The money line is Cleveland -140, Chicago -120. Over-under is 8 runs. Guardians are 5-4 ATS this season. Chicago is 3-6 AET this year.

Cleveland and Chicago are playing Guardians on April 20th. The money line is Cleveland -140, Chicago +120. Guardians are 5-4 ATS this season, while Chicago is 3-6 AET this year.

Cleveland Guardians are coming off a tough series against San Francisco. The team was outstanding during a four-game winning streak prior to that series. Third baseman Jose Ramirez is off to a red-hot start, batting .457 with three home runs through his first 35 at-bats. First baseman Owen Miller has provided an immediate boost, racking up 14 hits at a .500 clip. Starting pitcher Shane Bieber has allowed just a pair of hits in each of his two starts this season. Bieber is 5-2 with a 2.55 ERA in 12 career starts against Chicago.

Dallas Keuchel will start for Chicago against Cleveland on Wednesday afternoon. Chicago is coming off a loss to Tampa Bay, but it has won six of its last eight games. The White Sox are well-rested after wrapping up a six-game homestand on Sunday afternoon, led by Tim Anderson.

SportsLine's model is leaning over on the run total. It also says one side of the money line has all the value.