Cardinals vs. Seahawks Predictions, Picks & Odds Week 7: Seattle too Hot for Arizona

Our Arizona Cardinals-Seattle Seahawks predictions based on the best NFL odds examine a matchup between two NFC West rivals coming off a Week 6 loss.

Kyler Murray returned to practice for the Arizona Cardinals this week, although he's unlikely to play in Sunday's game. Arizona is 1-5 in 2023 without its 2019 No. 1 overall pick. Joshua Dobbs has completed just 49.3% of his pass attempts over the signal-caller's last two games. 

Meanwhile, the Seahawks have won three straight games against the Cardinals, one shy of their longest win streak in the series all time. Head coach Pete Carroll has masterminded 17 wins over Arizona during his time in Seattle.

Here is our best Cardinals-Seahawks prediction and our NFL picks (odds via our best NFL betting sites; pick confidence based on a 1-to-5-star scale).

Cardinals vs. Seahawks prediction

Seahawks -7.5 (-110 via DraftKings, BetMGM, and bet365) ⭐⭐⭐⭐

The Arizona Cardinals have lost their last three straight games while giving up an average of 32 points. They've averaged 15 points per game offensively during that span. 

Arizona’s strength on offense is its running game. The Cardinals rank second in the league in yards per carry (5.3), behind only the Miami Dolphins (6.5). Seattle has held its opponents to 3.2 yards per carry in 2023, the NFL's lowest mark. The Seahawks and Lions are the only NFL teams yet to allow a 20-yard rush.

Seattle is seventh in the league in passing yards per game (247) and 15th in rushing (104.2), while the Cardinals are allowing 266.3 passing yards (27th) and 133.3 rushing yards per outing (24th). The Seahawks’ Geno Smith has completed at least 60% of his pass attempts in nine straight games, the league's longest active streak. 

The Seahawks also boast a lethal ground game. Kenneth Walker’s six rushing touchdowns are the most from any Seahawk through the first five games of a season. Walker has scored a touchdown in each of his last four games. 

Seattle will overwhelm the Cardinals and comfortably cover.

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Cardinals vs. Seahawks best odds

DraftKings, BetMGM, and bet365 (-110)

The Cardinals’ flaws are starting to show after a feisty start to the season. Seattle will be able to scheme up an offensive attack through the air and on the ground. The Seahawks are 3-2 against the spread in 2023, and Arizona is 1-2 ATS on the road. 

Caesars is posting the line at 8, which is more than our other best sportsbooks. DraftKings, BetMGM, and bet365 are offering the best value at -110. 

Cardinals vs. Seahawks odds

The Seahawks are clear favorites in this matchup while priced as low as -400 on the moneyline at FanDuel. You can grab Arizona at +315 through the same book. The Seahawks are 3-2 straight up this season, while the Cardinals are 1-5. 

The total is at 44.5, which is a tough line because of Arizona’s faltering offense. The Over is 4-2 in games involving the Cardinals in 2023, and the Under has been 3-2 in Seahawks games. 

Also, Kenneth Walker is -160 to score a touchdown at Caesars.

Cardinals vs. Seahawks game info

• When: Sunday, October, 22 at 4:05 p.m. ET
• Where: Lumen Field, Seattle, WA
• How to watch: Fox 
• Weather: 55 degrees, 0% chance of precipitation, 6 mph winds

Cardinals-Seahawks prediction made 10/20/23 at 3:30 p.m. ET

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