Panthers vs. Seahawks Predictions, Picks & Odds Week 3: Don’t Sleep on Seattle

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Panthers vs. Seahawks Predictions, Picks & Odds Week 3: Don’t Sleep on Seattle

We're making our top Carolina Panthers vs. Seattle Seahawks predictionsbased on the best NFL odds with the Seahawks 0-1 at homethis season. Will quarterback Geno Smith light up Lumen Field against the winless Panthers?

After an unconvincing season start,the Seattle Seahawks went on the road and pulled off an impressive overtime win against the Detroit Lions in a shootout. Seattle quarterback Geno Smith showed glimpses of the QB that won Comeback Player of the Year last year, completing 32 of 41passes for 328 yards, two touchdowns, and no interceptions.

It looks like the Carolina Panthers will be withoutrookie quarterback Bryce Young, who missed practice Wednesday and Thursdaydue to an ankle injury. Andy Dalton is expected to replace him. Points have beenhard to come by for Carolina, so will ‘Red Rifle’ cause an upset in Seattle?

As part of our NFL best bets for Week 3, here is our best Panthers vs. Seahawks prediction and NFL picks (odds via our best NFL betting sites; pick confidence based on a1-to-5-star scale).

Panthers vs. Seahawks prediction

Seahawks -5.5 (-105 via FanDuel)⭐⭐⭐⭐

The Carolina Panthers started 0-2 whilescoring under 20 points in each game for the first time since 2010 when theystarted 0-5 and failed to record 20 points in each of those matchups. Meanwhile,the Seahawks scored at least 20 points in all five regular-season home meetings against Carolina.

Young is the first player this century torecord 160 or fewer passing yards and at least 30 attempts in each of his firsttwo NFL starts, and he's likely to miss this game due to injury. Whether it's Young or Dalton under center, either faces a challenge against Seattle’s defense. TheSeahawks' D forced negative yardage on 10 opponent rushattempts this season, an NFL-most. Seattle also allowed 2.45 yards perrush on first down in 2023, a league-lowest. 

If Carolina relies on its backsto support the QB, it'll have a hard job movingthe ball. Seattle’s O-line should withstand an injuredPanthers' defensive front. Expect a solid ground game from Seahawks running back Kenneth Walker III,who rushed for two TDs last week, along with a choice of top-classreceivers at Smith’s disposal.

It's a long trip cross-country for thePanthers, who have the inferior roster. The spread is less than a touchdown,so expect Seattle to cover.  

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Panthers vs. Seahawks best odds

The Seahawks began as 4-point favorites, andthat moved as high as -6.5 with some of our best sports betting apps. At the start of Friday, four of our best sports betting sites had the line at -6, but that dropped to -5.5. This might bebecause Dalton is likely to be the starter against Carolina. Panthers rusher Miles Sanders’ health status was also upgraded fromquestionable to healthy.

Carolina linebacker Shaq Thompson is out for the year, and cornerback JayceeHorn is a big loss in the Panthers’ secondary with Hawks' wideouts D.K. Metcalfand Tyler Lockett bearing down on them. This could be a mismatch in quality anddepth. 5.5 points is a good line for Seattle, who looks forits first home win of the season.

Panthers vs. Seahawks odds

The total was set at 42.5 points atDraftKings. With Carolina’s offensive struggles, bet on the Under. If theSeahawks take an early lead, they could run the clock with their ground game.

Caesars has Seattle -240 SU. Get +196 forCarolina on the moneyline at the same sportsbook.

Panthers vs. Seahawks game info

  • When: Sunday, Sept. 24 at 4:05 p.m. ET
  • Where: Lumen Field, Seattle, WA
  • How to watch: CBS
  • Weather: 59 degrees, 35% chance of precipitation, 5-mph winds

Panthers-Seahawks prediction made Friday, 9/22/23 at 1:37p.m. ET

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