Jaguars vs. Bills Prediction, Picks, Odds Week 5

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06 October 2023

Jaguars vs. Bills Prediction, Picks, Odds Week 5

Trevor Lawrence and the Jacksonville Jaguars have stayed in London all week since beating the Atlanta Falcons at Wembley Stadium last Sunday, this weekend they’re the road team to the Buffalo Bills on the other side of the city. Read on for our Jaguars vs. Bills predictions based on the best NFL odds

No team in NFL history has won consecutive regular season games outside of the U.S. Last week the Jacksonville Jaguars beat the Atlanta Falcons 23-7 at Wembley Stadium and have had a full week of practice in England, whereas the Buffalo Bills flew in on Friday. However, that extra time for acclimatization has not always worked in the teams’ favor.

Josh Allen and the Bills are on fire right now but lose their home advantage against a Jaguars franchise that has made London its second market. Which quarterback will come out on top when making your NFL best bets for Week 5?

To complement our Jaguars-Bills NFL player props, here is our best Jacksonville Jaguars vs. Buffalo Bills prediction and our NFL picks (odds via our best NFL betting sites; pick confidence based on a 1-to-5-star scale).

Jaguars vs. Bills prediction: London, Week 5

Over 48.5 (-110 via bet365) ⭐⭐⭐⭐

This will be the second time these two teams have met in London. The Jags got their first-ever win in the UK when they beat the Bills 34-31 at Wembley in 2015.

The Jaguars and Bills have faced each other 18 times and each team has nine wins in the series. Every one of the last six matchups has been decided by seven or fewer points with the last two each decided by three points.

The Bills head to London in excellent form. They’ve won three straight games by at least 28 points, the longest such streak by any team since the Bills themselves in 2020. The only team in NFL history to win four straight games by 28-plus points was the 1942 Chicago Bears.

Trevor Lawrence is going to have to be at the peak of his powers to keep up with Josh Allen and the Buffalo offense. Lawrence threw for 207 yards and ran for another 42 yards against Atlanta last week. He has had 40-plus rushing yards in three of his last 13 regular season starts after never reaching 40 yards on the ground in any of his first 25 starts.

Allen threw four touchdowns and no interceptions in Week 4 against the Miami Dolphins, his ninth career game with four-plus passing TDs and zero interceptions (including the postseason).

There has been a feel-good factor among the Jags in London this week. Head coach Doug Pederson said the mood has been different. He might have to pull some tricks out of his locker to surprise Buffalo.

The Bills were very content when they arrived at their practice facility on Friday. Von Miller has traveled with the team and said he is 94% sure that he will play. Allen and Stefon Diggs warned the league that they’re still finding ways to get better as a duo.

This game could be a fun one, so we’ll back the points as part of our NFL predictions for Week 5.

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Jaguars vs. Bills best odds

The total is understandably high for this matchup, because of the stars at quarterback. The Bills have proven that they can put up points against anyone. They’re averaging 34.8 points per game this season, and only the Dolphins (37.5 PPG) are averaging more. The Jaguars are averaging 20 points per game. Both Jacksonville and the Bills are 2-2 to the Over this season.

Thursday, DraftKings had kept the total at 48, while our other best sports betting apps set the line at 48.5. DraftKings has raised the total to match the other four best sports betting sites. It’s still good value, especially with the firepower on show in the UK.

Jaguars vs. Bills odds

The Jaguars are 5.5-point road underdogs for this game. London is their ‘home away from home’ and they’ve been in the UK for the past week. Considering how close recent encounters between these two teams have been, backing the Jags to cover could be the sensible option. They are -110 on the spread with all of our best sportsbooks. Jacksonville is 1-0 ATS on the road this season. The Bills are 3-1 against the spread overall.

Jacksonville is +205 straight up for this matchup. The Jags are 0-1 SU as underdogs this season, but 2-2 SU overall. Buffalo is the -235 favorite at DraftKings. The Bills are 3-1 SU this season.