UFC on ESPN 43: Holly Holm vs. Yana Santos odds, picks and predictions

In a women's bantamweight bout on the main card, Holly Holm and Yana Santos meet at UFC on ESPN 43 at AT&T Center in San Antonio, Texas. Let's analyze Tipico Sportsbook's lines around the UFC on ESPN 43: Holm vs. Santos odds, and make our expert picks and predictions.

The fights are on ESPN/ESPN+, with the prelims beginning at 4:30 p.m. ET. The main card, also on ESPN/ESPN+, begin at 7 p.m. ET.

Holm looks to avenge a split-decision loss against Ketlen Vieira last time out in the main even on May 21, 2022. Since her stunning KO/TKO of Ronda Rousey at UFC 193, "The Preacher's Daughter" has been rather ordinary. She is just 4-6 in the past 10 fights, and she has just 1 finish June 17, 2017, against Bethe Correia.

Santos is also looking to rebound after a 1st-round KO/TKO loss to Irene Aldana on the UFC 264 card July 10, 2021. She hasn't fought in nearly 2 full calendar years, 20 months to be exact, to give birth to a baby with husband Thiago Santos. It's the 2nd time in her career she pressed the pause button for the birth of a child.

The southpaw Holm holds a 1-inch reach advantage, and 2-inch height advantage, while Santos has a 4.28-to-3.24 significant strikes landed per minute advantage. In addition, Santos is much more accurate at 72.04% on her significant strikes, as opposed to Holm at 48.44%.

Santos can also wow the judges with her takedown ability, posting a 1.53 takedown average, while managing a 53.33% takedown average accuracy percentage.

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UFC on ESPN 43: Holm vs. Santos odds

Tipico Sportsbook; access USA TODAY Sports Scores and Sports Betting Odds hub for a full list. Lines last updated at 9:05 a.m. ET.