2021 Cheez-It Bowl prediction, odds, spread, line: Clemson vs. Iowa State picks from model on 43-30 run

The Clemson Tigers are two-point favorites in the latest Cheez-It Bowl odds. The game is scheduled for Wednesday at 5:45 p.m. ET at Camping World Stadium in Orlando, Florida. Iowa State is making their fifth consecutive bowl game. SportsLine's computer model simulates every FBS college football game 10,000 times. It has generated a profit of almost $3,600 for $100 players on its top-rated college Football Bowl Game picks against the spread.

Clemson is 14-2 against the spread in their last 16 games in December. Iowa State is 5-0-1 in the Cyclones' last six bowl games as an underdog.

Will Shipley needs three rushing touchdowns to tie Travis Etienne for the Clemson class record. Myles Murphy leads the Tigers in sacks with seven for 38 yards. He also is among the team leaders in tackles with 34, including 20 solo.

Iowa State has won five straight Big 12 titles. Tight end Charlie Kolar is second on the team in receiving with 58 catches for 723 yards and five touchdowns. Senior linebacker Jake Hummel leads the Cyclones in tackles with 76, including 37 solo.

SportsLine's model is leaning under on the total and projecting 42 combined points for Clemson vs. Iowa State. It has also generated an against-the-spread pick that cashes in nearly 60 percent of simulations.