Clemson vs. North Carolina State prediction, odds: 2022 Week 5 college football picks, best bets by top model

Clemson is looking to tie the longest home winning streak in ACC history at 37 games. The Tigers' last home loss was a 43-42 decision to Pittsburgh on Nov. 12, 2016. Florida State had the previous record of 58 games at home from 1992 to 2001. Clemson leads the all-time series 59-29-1.

Clemson and North Carolina State are playing each other in the Week 5 college football game. The Wolfpack are 5-2 against the spread in their last seven games against a team with a winning record. Clemson is 20-9 ATS in its last 29 games after scoring more than 40 points in a game and is favored by 7 points.

Clemson and North Carolina State are playing each other in the Week 5 college football game. The Wolfpack are 5-2 against the spread in their last 7 games against a team with a winning record. Clemson is 20-9 ATS in its last 29 games after scoring more than 40 points.

DJ Uiagalelei has been on a tear for Clemson this season. He has completed 83 of 129 passes for 1,033 yards and 10 touchdowns. Will Shipley has rushed for 353 yards (6.8 average) and 7 touchdowns this year.

North Carolina State is led by quarterback Devin Leary. Last week, Learys connected on 32 of 44 passes for 320 yards and four touchdowns in a 41-10 win over Connecticut. The Wolfpack's top receiver is fifth-year senior wide receiver Thayer Thomas. Thomas has had at least two catches in each game this season.

SportsLine's model is leaning Over on the total and against-the-spread.