49ers vs. Seahawks prediction: Odds, NFL playoffs game picks

The 49ers and Seahawks are playing each other for the third time this season.

49ers vs. Seahawks is an NFL playoffs game. Ohio sports betting is live.

The 49ers are a home favorite against Seattle in the NFL playoffs. San Francisco won the season series 2-0. The game starts at 4:40 p.m. ET on Fox.

The 49ers are on a 10-game win streak and have outscored teams by 16 points per game since Nov. 1. The rookie quarterback Brock Purdy has been playing well recently. Seattle has found success this year behind resurgent passer Geno Smith. The Seahawks are favored by 7 points. San Francisco is the better team with the best collection of skill-position players and the most suffocating defense. They also have the highest turnover margin and a better DVOA. It's a game to watch. 49er's are the favorite.