Thursday Night Football odds, spread, line: Seahawks vs. 49ers prediction, NFL picks by expert on 19-6 roll

The San Francisco 49ers host the Seattle Seahawks on Thursday Night Football at 8:15 p.m. ET. The 49er's lead the NFC West, but they are trailing the Eagles, Cowboys and Vikings for the best record in the division. Seattle is two games behind the 49erns in second place in NFC, and it's behind Commanders and Giants. SportsLine's Josh Nagel has covered the wagering industry for 20 years and has won numerous sports handicapping contests. He has hit 54% of his NFL picks against the spread since the start of the 2016 season.

Seahawks vs. 49ers is a Thursday Night Football game. The over/under for the game is 43.5 points. San Francisco is the league's top scoring defense.

Seahawks vs. 49ers is Thursday Night Football. The 49er's money line is San Francisco -190, Seattle +158.

The 49ers are the best defense in the NFL. They lead the league in scoring defense (15.2 points per game) and total defense. The team has dominated Seattle this season, winning the turnover battle 3-0 and limiting the Seahawks to just 36 rushing yards in Week 2.

Geno Smith is having a career year at quarterback for Seattle. The Seahawks are sixth in the league in scoring offense (26.3 points per game). San Francisco is without its top offensive playmaker, Deebo Samuel.

Seahawks are playing the 49ers on Thursday Night Football. SportsLine's Mike Nagel is picking the Seahawks.