Astros vs. Phillies odds, line: 2022 World Series Game 6 picks, predictions from proven model on 20-13 roll

Game 6 of the 2022 World Series is on Saturday at 8:03 p.m. ET at Minute Maid Park in Houston. Framber Valdez will take the ball for Houston, while Zack Wheeler is Philadelphia's pick. Caesars Sportsbook lists Houston as the -145 favorite (bet $145 to win $100). Philadelphia is +122 as an underdog. The over/under is listed at 7 runs and the Astros are -1.5 on the run line for a +150 payout. SportsLine's proven computer model simulates every MLB game 10,000 times and has returned more than $400 on its money-line bets.

SportsLine's advanced computer model has picked the 2022 World Series between Houston Astros and Philadelphia Phillies. The model is on a 20-13 roll. Philadelphia is 7-0 in their last seven games following an off day. Houston is 5-1 in its last five Saturday games.

Phillies vs. Astros money line is Philadelphia +122, Houston -145. The over-under is 7 runs. Houston is 5-0 in their last five Saturday games.

The starting pitchers in this game have been struggling recently. Valdez has only allowed one earned run in his last two starts. Houston has won consecutive road games to break Philadelphia's confidence. The Phillies have not been the same team away from home this season.

The Phillies are playing in the 2022 World Series. They are up 2-1 in a best-of-seven series against the Houston Astros. Bryce Harper, Rhys Hoskins and Kyle Schwarber have combined to hit 17 home runs this postseason. The team will be hoping that Valdez will start for the third time in one month.

SportsLine's model is leaning Over on the total and projects 7.7 combined runs. One side of the money line has all the value. SportsLine has a proven model on a 20-13 roll.