Broncos vs. Colts odds, line, spread: Thursday Night Football picks, NFL predictions from computer model

Denver Broncos host Indianapolis Colts on Thursday Night Football. The Colts are without star running back Jonathan Taylor, who is out with an ankle injury. Denver is a three-point favorite. Over/under for total points is 42. Colts lost to the Tennessee Titans last Sunday. Broncos fell to Las Vegas Raiders 32-23.

Broncos vs. Colts is Thursday Night Football. Denver is 3-point favorite. The over/under is 42 points. Indianapolis is 5-1 against the spread in their last six games following a straight-up loss.

Denver and Indianapolis are playing each other. Denver is favored by 3 points. Indianapolis is 5-1 against the spread in their last six games following a straight-up loss.

Denver's defensive line has players who can create pressure and get after the quarterback. Dre'Mont Jones is solid against the run with pass-rush moves to get into the backfield. Bradley Chubb is another force off the edge for the Broncos. Patrick Surtain II has been playing well through the first quarter of the season.

Colts are 10th in passing yards allowed (207.5). Cornerback Kenny Moore II excels as a blitzer off the edge and has natural ball-hawking skills. Stephon Gilmore is still a strong and well-rounded corner on the outside. Safety Rodney McLeod is a savvy veteran on back end.

SportsLine's model is leaning Under the total and calling for 40 combined points. It also says one side of the spread cashes in well over 50% of simulations.