Broncos vs. Panthers prediction, odds, spread, line: 2022 NFL picks, Week 12 best bets from proven model

The Carolina Panthers (3-8) are hosting the Denver Broncos ( 3-7) at Bank of America Stadium at 1 p.m. ET. The Panthers are making the move to Sam Darnold as their starting quarterback after Baker Mayfield struggled in the team's 13-3 loss to the Baltimore Ravens in Week 11. Denver is hoping to bounce back from a disappointing 22-16 overtime loss against the Las Vegas Raiders.

Broncos vs. Panthers is a Week 12 NFL game. The game is currently being played at Denver. There are several NFL odds and betting lines for the game, including a spread of 1/1 and a money line of 105/115.

Broncos vs. Panthers is a game with a potential score of 36.5 points. The money line is Carolina -105 and Denver -115.

Denver lost to the Las Vegas Raiders in overtime last Sunday. The Broncos are ranked No. 2 in the NFL in scoring defense and No 3 in total yards allowed per game.

Carolina lost to Baltimore Ravens 13-3. The team's rushing game was ineffective. Sam Darnold will start for the team against Denver. Denver is the favorite. Denver and Carolina are both 2nd in the league in yards per game.

The model simulates Broncos vs. Panthers 10,000 times and it's leaning Over on the point total. One side of the spread has all the value.