Broncos vs. Colts odds, line, spread: Thursday Night Football picks, NFL predictions by model on 140-105 run

The Denver Broncos and Indianapolis Colts are playing each other on Thursday Night Football. The Colts lost to the Tennessee Titans 24-17 last week, while the Broncos lost against the Las Vegas Raiders 32-23. Caesars Sportsbook lists Denver as a 3-point favorite in the latest Broncos vs. Colts odds.

Broncos vs. Colts is Thursday Night Football. Denver is a 3-point favorite. The over/under is 42.5 points. Indianapolis is 5-1 against the spread in their last six games following a straight-up loss.

Denver and Indianapolis are playing each other. Denver is favored by 3 points. Colts are 5-1 against the spread in their last six games following a straight-up loss. Broncos are also 5 of their 5 home games against teams with losing road records.

Jerry Jeudy is second on the team in catches (11), receiving yards (183), and owns a team-high two scores. Kendall Hinton has been a solid slot weapon and is comfortable with the ball in his hands. K.J. Hamler is a vertical weapon who reeled in a 55-yard pass in the loss against the Las Vegas Raiders.

Matt Ryan has struggled with turnovers and interceptions, but he's a savvy veteran quarterback. Michael Pittman Jr. owns top-notch ball skills with sticky hands to snag passes. Pittmann Jr is leading the team in receptions (20) and receiving yards (224).

SportsLine's model is leaning Under the total and says one side of the spread has all the value. SportsLine is on a 140-105 run.