Saints vs. Panthers prediction, odds, line, spread: 2022 NFL picks, Week 3 best bets from proven model

Carolina Panthers and New Orleans Saints are playing each other in 2022 at 1 p.m. ET on Sunday at Bank of America Stadium in Charlotte. The Panthers are looking for their first win in the season after losing their opening two games by a combined 5 points. New York Saints lost 20-10 to Tom Brady and the Buccaneers last Sunday. All-Pro running back Alvin Kamara is questionable for the game.

SportsLine's advanced computer model has set its sights on Panthers vs. Saints and has made its picks and NFL predictions. Panthers are favored by 2.5 points.

Saints vs. Panthers is a game with a total of 41 points. The line is Saints -2.5.

Saints defense has been inconsistent this season. Quarterback Jameis Winston has struggled against the Panthers in his 10 career starts. In his one start against Carolina in 2021, Winston had 111 yards passing, took four sacks and threw two interceptions.

The Panthers are in desperate need of a win. They haven't taken a single turnover in two games. Baker Mayfield has been inconsistent in his first season with the Panthers. He has completed 53.6% of his passes for 380 yards, two touchdowns and one interception.

The model simulates Panthers vs. Saints 10,000 times and it's picking the Panthers. It's leaning Over on the point total and says one side of the spread hits more than 50% of time.