49ers vs. Seahawks prediction, odds, line, spread: 2022 NFL picks, Week 2 best bets from proven computer model

The Seattle Seahawks and the San Francisco 49ers are playing each other at 4:05 p.m. ET on Sunday at Levi's Stadium in Santa Clara. The Seahawks lead the all-time series 30-17 and have won five of the last six meetings in this rivalry. San Francians lost to the Chicago Bears in the opener, while the Seahawks beat the Denver Broncos on Monday Night Football.

The model has set its sights on 49ers vs. Seahawks and has made its Week 2 NFL picks and predictions. The model is using the following odds and betting lines: 49er's vs Seahawks is a 10-point favorite.

The 49ers lost 19-10 to the Chicago Bears in a rainstorm. Quarterback Trey Lance was the team's leading rusher with 54 yards on 13 carries. Wide receiver Deebo Samuel had a quiet afternoon with 52 yards and a touchdown on eight carries and catching two passes for 12 yards. Elijah Mitchell is out indefinitely and George Kittle is questionable.

Seattle Seahawks beat Denver Broncos 17-16 last week. Quarterback Geno Smith was nearly perfect in the first half. All-Pro safety Jamal Adams suffered a season-ending quad injury. Uchenna Nwosu was named NFC Defensive Player of the Week.

The model simulates 49ers vs. Seahawks 10,000 times and has generated a point-spread pick that is hitting in well over 50% of simulations. The model is leaning Under on the total.