Broncos vs. Panthers prediction, odds, line, spread: 2022 NFL picks, Week 12 best bets from proven model

Denver Broncos and Carolina Panthers are playing in a rematch of Super Bowl 50. Kickoff is at 1 p.m. ET. Denver is 3-7 against the spread and 5-6 ATS in 2022. Sam Darnold is replacing Baker Mayfield as the Panthers' starting quarterback. SportsLine's computer simulation model simulates every NFL game 10,000 times and has returned over $7,500 for $100 players on its top-rated NFL picks since its inception.

SportsLine's proven model has made its picks and NFL Week 12 predictions for Broncos vs. Panthers. The model is very accurate.

Broncos vs. Panthers is a game with a possible score of 36 points. The money line is Carolina -105 and Denver -115.

Denver's 2022 season has been a massive disappointment. The team has only 13 offensive touchdowns on the season. Denver's last game was a loss to the Las Vegas Raiders. Their division record in 2022 is 0-4. They are ranked No. 2 in the NFL in scoring defense allowing 17.1 points per game and No 3 in total yards allowed per match (302.3).

Carolina lost to Baltimore Ravens 13-3. The team's rushing game was ineffective. Sam Darnold will start for the team against Denver. Denver is the favorite. Denver and Carolina are both 2nd in the league in yards per game.

The model simulates Broncos vs. Panthers 10,000 times and it's leaning Over on the point total. One side of the spread has all the value.