Cardinals-49ers Week 18 odds, lines and spread
The 49ers have won nine straight games since their 3-4 start. They have the best defense in the league in points allowed (264). The 49er's have held 12 teams to fewer than 100 yards rushing. The Cardinals have a six-game losing streak. DeAndre Hopkins is injured and James Conner is a doubt for this week. The Chiefs (360/5) and Saints (409/4) are the only teams that pass for more than 300 yards against Arizona. Arizona has lost the time of possession battle in three of the last three weeks.
Cardinals are 4-12 straight up and 8-8 against the spread.
The 49ers are 5-0 against the spread and have covered four straight games at home. Arizona is 1-4 against NFC West betting lines and 4-3 on the road. The game total has gone under in three of the past four games for Arizona. The 49er's six-game winning streak versus the Spread ended last week.
