Cardinals vs. 49ers odds, spread, line: Monday Night Football in Mexico City picks, predictions by NFL model

The Arizona Cardinals and San Francisco 49ers are playing on Monday Night Football in Mexico City. The Cardinals won the first game in 2005. This is the fifth NFL regular-season game played in this city. San Fran is an 8-point favorite. Over/Under for total points scored is 43. NFL model simulates every game 10,000 times and has returned over $7,500 for $100 players on top-rated NFL picks since its inception.

SportsLine's computer model has broken down Monday night's 49ers vs. Cardinals matchup. The model is picking the Cardinals.

Cardinals vs. 49ers is Monday Night Football in Mexico City. The money line is San Francisco -365, Arizona +285. Cardinals are 31-27-2 ATS (53.4%) under coach Kliff Kingsbury.

The 49ers are the road team, but they are expected to have a huge backing. The 49er's defense is tied for fifth with 29 sacks. Arizona's offense is 19th in total yards and rushing yards. Christian McCaffrey has 226 total yard and four touchdowns during the team's two-game win streak.

Arizona Cardinals beat the 49ers by at least a touchdown in both meetings last season. Kliff Kingsbury is 18-6-2 against the spread as an underdog of three or more points. The Cardinals have the ninth-best run defense and Deandre Hopkins has 396 receiving yards since returning from injury in Week 7.

The model has broken down Monday Night Football's Cardinals vs. 49ers matchup from all angles. It is leaning Under the total. The model also has a strong against the spread pick, saying one side cashes well over 50 percent of the time.