Chicago Cubs at San Francisco Giants odds, picks and predictions

The Chicago Cubs (27-36) and San Francisco Giants (32-31) meet Saturday for the 2nd game of a 3-game series. First pitch from Oracle Park is set for 7:35 p.m. ET (FOX). Let’s analyze BetMGM Sportsbook’s lines around the Cubs vs. Giants odds and make our expert MLB picks and predictions for the best bets.

Season series: Cubs lead 1-0

Chicago won 3-2 as a +103 road underdog Friday in the series opener. San Francisco held a 1-0 lead off the back of an RBI double in the 3rd inning from 2B Thairo Estrada but the Cubs capitalized on a 3-run 7th inning to secure the victory.

Friday’s game snapped a 4-game losing skid for Chicago and 3-game win streak for San Francisco. The Cubs have won 4 of their last 10 games and are 12-20 on the road while the Giants are 5-5 in their last 10 outings and 17-16 at home.

Cubs at Giants projected starters

RHP Kyle Hendricks vs. RHP John Brebbia

Hendricks (0-2, 4.70 ERA) makes his 4th start. He has a 1.50 WHIP, 2.9 BB/9 and 7.0 K/9 through 15 1/3 IP.

• Last outing: Loss, 6 IP, 4 ER, 6 H, 0 BB, 4 K in a 5-0 road loss vs. the San Diego Padres Monday
• Career vs. San Francisco: 5-2 with a 2.29 ERA (63 IP, 16 ER), 1.00 WHIP, 19 BB, 53 K across 10 starts

Brebbia (2-0, 3.65 ERA) makes his 6th start and 27th appearance. He has a 1.14 WHIP, 2.9 BB/9 and 12.0 K/9 through 24 2/3 IP.

• Last outing: No-decision, 1 IP, 0 ER, 2 H, 1 BB, 0 K in a 10-4 road win Tuesday vs. Colorado Rockies as an opener
• Career vs. Chicago: 1-2 with a 4.66 ERA (19 1/3 IP, 10 ER), 8 BB, 18 K, 1.40 WHIP across 1 start and 19 relief appearances
• Has yet to pitch more than 1 1/3 inning in any of his 5 starts

Cubs at Giants odds

BetMGM Sportsbook; access USA TODAY Sports Scores and Sports Betting Odds hub for a full list. Lines last updated at 11:30 a.m. ET.

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Cubs at Giants picks and predictions

Prediction

Giants 4, Cubs 3

LEAN GIANTS (-150).

The Giants are 7-3 in the last 10 meetings with the Cubs and have won two of the last 3 times they’ve squared off. The Cubs have struggled on the road and while the Giants are not a great home team it is still hard for me to believe that they will allow Chicago to come away with back-to-back road games.

PASS.

The line here simply isn’t worth the juice, bet on the moneyline and/or O/U instead.

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BET UNDER 8.5 (-105).

Chicago has played to 3 straight Unders and the Under is 9-1 in its last 10 games. The Under is 6-4 in San Francisco’s last 10 games and 3-0 in their last 3 as well.

The Under is also 7-3 in the last 10 meetings overall and 5-0 in the last 5 meetings overall.

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