Chiefs vs. Seahawks prediction, odds, line, spread: 2022 NFL picks, Week 16 best bets from proven simulation

Kansas City Chiefs host Seattle Seahawks at 1 p.m. on Saturday. The Chiefs are 11-3 and are chasing the top seed in the AFC playoffs. Seattle is 7-7 and is favored by 10 points. SportsLine's advanced computer simulation simulates every NFL game 10,000 times. It has returned a massive 157-113 for its top-rated NFL picks since it was launched in 2017.

SportsLine's computer simulation has picked Chiefs vs. Seahawks. The model is also making NFL Week 16 predictions. Chiefs are favored by 10 points.

Chiefs vs. Seahawks is a game with a 50.5-point over/under. The money line is Kansas City -480 and Seattle -360.

The Chiefs have already clinched the AFC West title. They still have a chance at landing the No. 1 seed in the playoff bracket. The weather is expected to be ugly, so the Chiefs may have to rely on their rushing attack more than usual. Rookie Isiah Pacheco has been the team's leading rusher recently.

Seattle came up short against the San Francisco 49ers last Thursday, falling 21-13. Seattle has experienced some struggles of their own as they are second worst in the NFL in rushing yards allowed per game. The Chiefs rookie running back Isiah Pacheco is the star player for the Chiefs.

The model has simulated Chiefs vs. Seahawks 10,000 times and the results are in. It's leaning Over the point total and it says one side of the spread has all the value.