Saints vs. Seahawks prediction, odds, line, spread: 2022 NFL picks, Week 5 best bets from proven model

The New Orleans Saints (1-3) are set to host the Seattle Seahawks (2-2) at 1 p.m. ET on Sunday. New York lost 28-25 to the Minnesota Vikings in London and Seattle won 48-45 over the Detroit Lions in Week 4. Quarterback Jameis Winston is out for New Saints. Veteran Andy Dalton will start in place of Winston. Seattle is 2-1 against the spread and 1-4 ATS in 2022.

SportsLine's computer model has made its picks and NFL Week 5 predictions for Saints vs. Seahawks. The model is backing the Saints.

Saints vs. Seahawks is a game with a total of 45 points.

The Saints lost 28-25 to the Vikings in London. New Orleans has been inconsistent in the last four weeks. The Saints have a problem with ball security and are last in turnover percentage. They are the more talented team in this matchup. They have lost three games in a row.

Saints and Seahawks are playing each other in 2022. Seattle won the game against Detroit 48-45. Rashaad Penny had a stellar game for the Seahawks, rushing for two touchdowns and 151 yards on 17 carries. Geno Smith has played well for Seattle through four weeks. New Orleans has allowed only three passing touchdowns in the last four years.

The model simulates Saints vs. Seahawks 10,000 times and it has generated a point-spread pick that is hitting in well over 50% of simulations.