Clemson vs. Louisville Prediction, Odds, Lines, Spread, and Picks- November 12

Clemson Tigers lost to Notre Dame Fighting Irish last week. Louisville Cardinals have won four straight games.

D.J. Uiagalelei was terrible last weekend and a change in the Clemson Tigers' quarterbacking may be necessary. Will Shipley is a multi-talented runner who totaled just under 1,000 yards on the season. Malik Cunningham is the one-man show for the Cardinals, leading the team in passing and rushing. Tyler Hudson has been the go-to receiver for Clemson all season and is expected to be the Tigers go to receiver.

Clemson Tigers play Louisville Cardinals on November 12.

Clemson and Louisville are playing each other on Saturday, November 12 at 3:30 PM ET at Memorial Stadium, Clemson, South Carolina.

Clemson Tigers will be ready for Louisville Cardinals. Malik Cunningham will have to scramble out of the pocket. The defensive front will put pressure on Cunningham.

Clemson's offense has been poor recently. Louisville's defense will try to stop the Clemson run. The Cardinals will keep this one razor-sharp.