Louisville football vs. Clemson: 3 things to know, betting line

Louisville football team is 5-3, 3-2 in the ACC and 10-1 in all other conferences. They play No. 10 Clemson at 3:30 p.m. Saturday at Memorial Stadium in Clemson, South Carolina. The team started the season with a 2- 3 record and lost to Boston College. After a 34-17 win at Virginia, they won four games in five weeks.

DJ Uiagalelei is the starting quarterback for Clemson this season. Cade Klubnik is a true freshman. Louisville's defense is allowing 133.8 rushing yards per game. Will Shipley is an effective running back.  Louisville's last four games have been won by less than 100 yards. The Cardinals' defense has held opponents to less that 100 in two of the last 4 games. It's tied for 49th nationally. Virginia's 6 rushingyards on 25 carries on Oct. 8 was the worst.

Memorial Stadium is a hostile environment for opposing teams. Louisville hasn't been to Death Valley since a 77-16 blowout loss in 2018. Scott Satterfield experienced the stadium while he was coaching at Appalachian State in 2015. The Mountaineers lost 41-10. Louisville has been in hostile environments before this season, including Syracuse’s JMA Wireless Dome.

Louisville is looking to upset Clemson. The Cardinals have never beaten the Tigers in seven meetings. Last season, they lost 30-24. This year, the Cardinals are on a four-game winning streak. Louisville has one top-10 win this season. It's the first time the program has achieved that feat while being unranked since a double-overtime 26-20 victory over Florida State in 2002.

Clemson is a seven-point favorite over Louisville.

Louisville football is playing against Clemson. The Tigers have a home field advantage and a highly touted defense.