Louisville vs Clemson Odds, Picks & Predictions

Louisville is 6-3 and bowl eligible. Clemson is 10th in the CFP and lost at Notre Dame. The Tigers are coming off their first loss of the season. Louisville has won four straight games. It is yet to beat Clemson in seven tries.

Louisville beat James Madison 20-10 last Saturday. The game marked the first time in more than two decades that the Cards won a game under those circumstances. Louisville will play Clemson on Saturday, who lost to Notre Dame. The Cards forced eight turnovers in their previous game against Wake Forest. Clemson gave the ball away twice in the game, including on a 96-yard interception return in its 35-14 loss to the Irish. They will need to return to their dominance on defense to beat Clemson. It's been a while since they forced 8 turnovers. Their last game was against the previously-ranked team.

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Louisville is 4-0 against the spread in its last four games overall and 4.1 ATS versus teams with a winning record. The Cards are 2-1 as a road underdog this season. Clemson is 7-2 AET in last nine conference games and 5- 0 ATC in the last five meetings with Louisville. Tigers are just 1-3 AATS at home in 2022. Clemson lost to Notre Dame last Saturday. Louisville is trying to replicate its success against James Madison. Cardinals are trying not to repeat their success from Wake Forest.

Uiagalelei is expected to start again on Saturday. Clemson's coach is willing to pull him for Klubnik if he struggles. Louisville's offense is getting better from Cunningham. The total has settled between 51.5 and 52.6 points. The last time the total dipped below 54 was in the first two games between these programs.

Louisville vs. Clemson is a conference game. The Over is 4-1 in Louisville's last five conference games and 4 -1 over the last 5 meetings between these teams.

Louisville vs Clemson is a college football game.