Notre Dame vs. Clemson: Prediction, pick, spread, football game odds, live stream, watch online, TV channel

No. 4 Clemson is playing for the newly-minted College Football Playoff Ranking. Notre Dame is looking to improve on its recent performances. The last time the Tigers came to South Bend, they won the game. Clemson won a shootout at Wake Forest and won lower-scoring games against NC State and Syracuse. They also beat both Boston College and Florida State on the road.

DJ Uiagalelei started in 2020 game in place of Trevor Lawrence. DJU threw for 439 yards and three touchdowns. Trevor would return to the starter's role and Clemson would avenge the loss with a win in the ACC Championship Game. In 2021 DJ Uigaleli threw nine touchdowns to 10 interceptions and had the worst passer rating in ACC. He has 17 touchdowns and four interceptions in eight games in 2022.

Notre Dame's offense has been effective since the loss of quarterback Tyler Buchner. The team has run the ball 233 times since then and is averaging 228 rushing yards per game. The Fighting Irish boast a deep backfield with Audric Estime, Logan Diggs and Chris Tyree.

Clemson and Notre Dame have played each other four times in the last five seasons. Clemson leads the series 4-2. The Tigers won the 2018 College Football Playoff semifinals and the 2020 ACC Championship Game.

Notre Dame vs. Clemson is live streaming on the Internet and on TV.

Notre Dame vs. Clemson is a defensive battle. The game should be decided by field position and field goal attempts. SportsLine's computer model has returned almost $3,000 in profit over the past six-plus seasons.