Clemson vs Notre Dame Odds, Spread, Prediction & How to Watch

#4 Clemson has the longest current winning streak in the nation. It visits Notre Dame at 7:30 p.m. ET Saturday at Notre Notre Irish Stadium in South Bend, Indiana.

Clemson is a four-point favorite and a -190 pick on the moneyline in the college football odds. The Tigers’ National Championship odds are +1500. There is 60% chance of rain, mostly cloudy and low of 43 degrees.

Clemson is the last unbeaten team in the ACC. DJ Uiagalelei is still the starter. Cade Klubnik started the second half against Syracuse and had minimal impact. Will Shipley had 172 yards and two touchdowns on the ground in 27 carries. Antonio Williams is Clemson's top receiver. Barrett Carter is ready to return after concussion protocol.

Notre Dame's win over Syracuse was its 26th straight against an ACC opponent. Audric Estime and Logan Diggs both had 20 carries and they have combined for 989 yards this season. Brandon Joseph returned an interception 29 yards for a touchdown on the first play from scrimmage. Quarterback Drew Pyne was 9-of-19 passing for 116 yards with one touchdown and one interception. Tight end Michael Mayer leads the team with 47 receptions, 550 receiving yards and six touchdown catches.

Clemson leads the all-time series 4-2. The last meeting was in the 2020 ACC Championship Game. Notre Dame was an ACC member for one year only during the pandemic-altered season.