Syracuse vs. Notre Dame odds, prediction, betting trends for Week 9 matchup

Syracuse hosts Notre Dame at the JMA Wireless Dome (12:00 p.m. ET on ABC) in an intriguing non-conference matchup. Syracuse is looking to bounce back from a 27-21 loss to Clemson in Week 8. Notre Notre Ireland is seeking its fifth-straight win over Syracuse and its first since 2020.

Syracuse is 2.5-point home favorite against Notre Dame. The total has gone up to 48 from 45.

Syracuse is 6-1 ATS and 6th overall. Notre Dame is 5-0 ATC against ACC teams. Both teams are better defensively than offensively.

Last week, Syracuse's defense couldn't keep Clemson's rushing attack in check. Notre Dame has the 10th-best run blocking grade (77.0) and the 7th best run defense grade. Syracuse ranks in the bottom half of the FBS in its run defence grade of 73.1.

Syracuse lost to Clemson last week. The Orange generate three more turnovers than their opponent. If Syracuse doesn't manage to keep a positive turnover margin, it could spell trouble for its hopes of getting to 7-1.

Garrett Shrader has been one of the more underrated quarterbacks this season. He's been effective when he's not blitzed and when blitzing. Notre Dame's defense will try to sit back in coverage and force Shrerader to pick apart its defense.

Syracuse lost to Notre Dame last week. The Orange are the road favorites. Notre Notre is the favorite. The Fighting Irish are efficient on the ground. They can make it easy for Drew Pyne.

Syracuse vs. Notre Dame is a game with a total of 48.5 points.