College Football Odds: Indiana vs. Ohio State prediction, odds and pick

Indiana is on a six-game losing streak and is close to losing bowl eligibility for the second consecutive season. The Hoosiers are looking to beat Ohio State for first time since 1988.

The Buckeyes beat Northwestern by two touchdowns last weekend. They are going to play Indiana at home this weekend and need to score a lot of points.

Indiana started the season 3-0 but since then they have lost six games in a row. Tom Allen's team is struggling. The Hoosiers are favored by 39.5 points. They need to win the time of possession and the running game to cover the spread. They are only averaging 78 rushing yards this season. Their defense has been poor all year with an average of 423 yards allowed. Indiana needs to keep Ohio State off the field.

Indiana is a 39.5-point favorite against Ohio State. The Buckeyes are looking to win their 27th straight game. They only scored 21 points against Northwestern.

Ohio State lost to Northwestern last Saturday. They need to play well to cover the spread. Indiana has struggled to stop the rush this season. They are accumulating 193 rushing yards per game against the opposition this year. Ohio State needs to feed their running backs often. The defense needs a game to get right after getting gouged by Northwestern.

Indiana does not have the firepower to keep up with a national championship contending team like Ohio State.

Ohio State is favored by 39.5 points over Indiana.