College football odds, picks, predictions for Aug. 27, 2022: Computer simulation fading Illinois in Week 0

Nebraska and Northwestern are playing in the opening game of the college football season on Saturday, August 27. Hawaii hasn't hosted an SEC team in 19 years. Vanderbilt visits Hawaii at 10:30 p.m. ET on CBS Sports Network. Caesars Sportsbook has the Commodores as 9.5-point favorites in its latest Week 0 collegefootball spreads. SportsLine's proven computer model simulates every FBS collegeFootball game 10,000 times and has generated a stunning profit of almost $3,600 for $100 players on its top-rated college Football picks.

Wyoming and Illinois are playing a 7-point game in Champaign, Illinois. Wyoming has upgraded its aerial attack by adding graduate transfer Andrew Peasley from Utah State. The model is recommending Wyoming to cover the spread. The Over (43) clears with a couple points to spare. See which other teams the model likes here.

SportsLine's computer simulation is picking Illinois to lose to Ohio State in the first game of the college football season. It also has a model that predicts a big favorite to go down hard in a shocking upset.

Nebraska at Northwestern, UConn at Utah State, Wyoming at Illinois, Charlotte at FAU, North Texas at UTEP, Nevada at New Mexico State and Vanderbilt at Hawaii are the games on Saturday, August 27.