Nebraska vs. Northwestern odds, spread: 2022 college football picks, Week 0 predictions by model on 43-31 run

Nebraska Cornhuskers and Northwestern Wildcats play each other on August 27 at 12:30 p.m. ET at Aviva Stadium in Dublin, Ireland. The total number of points Vegas thinks will be scored is 52. Nebraska won the last meeting between the teams in 2021. SportsLine's advanced computer model simulates every FBS college football game 10,000 times. It has generated a profit of almost $3,600 for $100 players on its top-rated college game picks against the spread.

Nebraska and Northwestern are playing each other in 2022. Nebraska is a heavy favorite. Northwestern is returning nine offensive starters. SportsLine's computer model has made 43-31 CFB predictions.

Nebraska vs. Northwestern money line is Nebraska -455, Northwestern +335. Nebraska outscored opponents by 63 points in 2021.

Nebraska signed quarterback Casey Thompson and wide receivers Trey Palmer, Marcus Washington, and Isaiah Garcia-Castaneda. On defense, Nebraska signed former TCU defensive end Ochaun Mathis. Nebraska is playing Northwestern in 2022. Northwestern struggled in 2021 and lost its last six games.

Northwestern is looking for revenge after losing to Nebraska last season. The Cornhuskers have a poor record in competitive games. Northwestern has a talented offensive line, including left tackle Peter Skoronski.

SportsLine's model is leaning Under on the point total. The model also says one side of the spread hits in well over 60% of simulations.