Purdue vs. Northwestern odds, line, bets: 2022 college football picks, Week 12 predictions from proven model

Purdue Boilermakers are trying to stay alive in the Big Ten West title race against Northwestern Wildcats. Northwestern has lost all nine of its games since opening the season with a win over Nebraska. Kickoff is set for noon ET. The Boilers are favored by 18.5 points in Caesars Sportsbook's latest Purdue vs. Northwestern odds.

SportsLine's computer model has picked Purdue vs. Northwestern. The model is using a college football spread of 18.5 points.

Purdue and Northwestern play each other in a college football game on Saturday. The game is expected to be very close.

Purdue beat Illinois last week as a 6-point underdog. Northwestern has lost nine straight games and covered the spread only four times in its last 13 games. The Wildcats have been outscored 256-122 during that stretch.

Purdue is coming off a huge road win against a ranked opponent. Northwestern has been using multiple quarterbacks recently. The Wildcats have covered the spread in four of the last six meetings between these teams.

The model simulating Purdue vs. Northwestern 10,000 times has picked the over in 60% of simulations.