College Football Week 5 Odds, Best Bets & Predictions

Georgia, Alabama and Ohio State are the favorites to win the College Football Playoff. Clemson and USC are also in the top three. This week Clemson is favored by less than a touchdown against No. 10 North Carolina State. Alabama is also a 16-point favorite at No 20 Arkansas.

College Football Week 5 of the 2022 season is taking place. There are some interesting betting lines for the games.

College Football Week 5 Odds, Best Bets & Predictions. Michigan vs. Iowa and Kentucky vs Ole Miss are the best bets.

Michigan is a double-digit favorite against Iowa. The Wolverines beat Maryland 34-27, but Iowa won 27-10 at Rutgers. Iowa has a history of beating top-5 teams at home.

Kentucky and Ole Miss are two unbeaten SEC teams playing each other in a huge Week 5 game at OleMiss. Kentucky won at Florida in Week 2, but hasn't looked stellar since. Ole Mississippi hasn’t been tested either, and they weren”t overly sharp in their 35-27 home win over Tulsa.

Iowa State plays at Kansas on Saturday at 3:30 p.m. ET. The Cyclones are 3-1 and the Jayhawks are 4-0. Iowa State won at Iowa in Week 2 and Kansas lost at Baylor.

Alabama is looking to make it 15 straight wins over Arkansas. Arkansas lost to Alabama 42-35 last year in Tuscaloosa. Alabama is 4-0 and looking for revenge after losing to Georgia in last season's national championship game.

Baylor is a slight favorite against Oklahoma State. The Cowboys are coming off a bye week and have beaten Arizona State and Arkansas Pine Bluff. Baylor is experienced and battle-tested. Oklahoma's defense is weak.

Wake Forest lost to Clemson last week. Florida State is favored by single digits. The Seminoles are coming off an impressive win over Boston College. Hurricane Ian is not expected to have a big impact on the game.

LSU is a home favorite against Auburn. The Tigers are struggling under coach Bryan Harsin. He almost got fired last weekend, but his team won at home over Missouri.

No. 10 North Carolina State is looking for its first win over Clemson since 2002. Last year's 27-21 upset win in Raleigh helped sink Clemson's ACC title chances. The Wolfpack would love to play spoiler for the second year in a row.