Colts vs. Chargers odds, line, spread: Monday Night Football picks, NFL predictions, best bets from top model

The Los Angeles Chargers take on the Indianapolis Colts on Monday Night Football in the 15th game of the 2022 campaign. The Chargers are 8-6 overall and 4-3 on road this season. Indianapolis is 4.9 overall after four consecutive losses. Nick Foles will be the starting quarterback for Indianapolis.

SportsLine's computer model has set its sights on Chargers vs. Colts and has made its picks and predictions. The model is using the following odds and betting lines: Colts vs Chargers spread: 4, Chargers money line: 210, Colts +175, over/under: 45.5 points.

Colts vs. Chargers is Monday Night Football. The Chargers are 8-5-1 against the spread this season. Colts are 6-8- against-the-spread this year.

The Chargers are playing much better on defense in recent weeks. Los Angeles has allowed only 31 points over the last two games. The Colts are No. 29 in the NFL in scoring and No 24 in total offense. They have committed more turnovers (27) and lost more fumbles (13) than any team in NFL.

The Colts are in the top five of the NFL in yards allowed per drive (27.5) and in top 12 of total defense (329.3 yards per game). They are stingy against the pass, giving up 205.6 passing yards and 4.1 yards a carry. Veteran linebacker Zaire Franklin has at least 10 tackles in five straight games.

SportsLine's model is leaning Over on the total. It projects 47 combined points for the Chargers and Colts. One side of the spread hits in over 50% of simulations.