49ers vs. Chargers odds, spread, line: Sunday Night Football picks, predictions by NFL model on 151-108 run

The San Francisco 49ers host the Los Angeles Chargers on Sunday Night Football at 8:20 p.m. ET. San Diego is a seven-point favorite in the latest 49er vs. Chargers odds. The over-under for total points scored is 45.5. SportsLine's advanced computer model simulates every NFL game 10,000 times and has returned an impressive 151-108 straight-up wins for its players since it was launched in 2017.

The model has set its sights on 49ers vs. Chargers and has made its NFL picks and predictions. San Francisco is 6-1 against the spread in their last seven home games. Los Angeles is 4-0 ATS on the road this season.

49ers vs. Chargers money line is San Francisco -335, Los Angeles +260. 49ers are 6-1 against the spread in their last 7 home games. The over/under is 45.5 points.

The 49ers are first in total defense and sixth in points allowed this season. Christian McCaffrey gained 94 yards on the ground and became the first player since LaDainian Tomlinson in 2005 to record a passing, rushing and receiving touchdown in the same game.

The Chargers possess a dangerous aerial attack. Austin Ekeler has recorded both a rushing and receiving touchdown four times over his last five games. Justin Herbert is fifth in the league in passing yards. He is tied with Andrew Luck for the most 300-yard performances through their first five seasons since 1950.

SportsLine's model is leaning Over on the total. It projects the teams to combine for 50 points. One side of the spread cashes in well over 50% of simulations.