Colts vs Jaguars Odds, Picks & Predictions

Colts and Jaguars play each other on Sunday, September 18th. Last season, the Colts were down 20-0 after three quarters and tied the game in overtime. The Jaguars lost their first game 28-22 away to the Commanders.

Matt Ryan had a good debut with Indianapolis. Ryan will target Michael Pittman, who is injured. Jonathan Taylor will play a big role in the Colts offense. The Jaguars defense will step up and cover the 3.5-point spread. Jags were beaten by Washington last week. Trevor Lawrence and Christian Kirk hooked up for 117 yards. Jacksonville was 2-5 in red zone and committed 13 penalties. They also had two turnovers. Colts defense played tough last time. It will do the same this time too.

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The Colts are 6-3-1 straight-up and 6.4-0 ATS as road favorites during the Frank Reich era. The Colts defense is going to put constant pressure on the Jaguars offensive line.

The Colts defense may bend, but it doesn't break. Washington pressured the Jags signal-caller into a couple of sacks. I expect the same things with equal or greater success from the Colts. The Under is 11-8-0 when the Indianapolis plays a division foe and 9-9-1 when Jacksonville plays its AFC South rivals.

Colts vs. Jaguars is a live NFL game.

Colts are 6-1-0 ATS in their last eight road games.