Colts vs. Jaguars Picks, Predictions NFL Week 2: Expect Indianapolis' Offense to Pop Off

The Indianapolis Colts and Jacksonville Jaguars will meet for the first time since their infamous Week 18 contest last season. Indianapolis didn't secure a win over the Houston Texans in Week 1, but it did manage to impress on the offensive side of the ball with new quarterback Matt Ryan. Jacksonville flopped against the Washington Commanders and will look to establish itself in the second game.

Colts and Jaguars are playing each other on Sunday, September 18 at 1 p.m. ET at TIAA Bank Field, Jacksonville, FL. The weather is expected to be 84 degrees with 70% chance of precipitation.

The Jaguars are 4.5 points underdogs against the Colts. The total is 45. 5 points. More than 70% of the money is on the Under 45, while 51% is paid for the ticket.

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The Jaguars took out the Colts in the last week of the 2021 season. Indianapolis is looking for revenge this time around. The Colts' defense ranked 10th overall and 10 th in rushing defense. Jacksonville struggled against Carson Wentz in Week 1. Jonathan Taylor is the best running back in NFL. The Jaguars' offense lags behind and their defense is full of question marks.

The Jaguars defense is going to be key for the team that won the game against the Colts. The Texans are a bad team, but they were able to score 20 points in a tie against Indianapolis last week.

Colts vs. Jaguars is a game to watch. The Jaguars were beaten by Commanders receivers Curtis Samuel and Jahan Dotson in the first game. Michael Pittman caught a touchdown in last week's game and is Ryan's clear-cut No. 1 option.

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Colts vs. Jaguars is on 9/15/2022 at 7:24 p.m. ET.