Detroit Lions vs Carolina Panthers Odds, Predictions and Best Bets for Week 16

Detroit Lions are a 2.5-point road favorite at Carolina Panthers. The teams have played only three times since 2014. Carolina is 4-6 SU and 6-3 ATS since Steve Wilks replaced Matt Rhule as head coach.

Detroit Lions are on a big turnaround story. They have won six of their last seven games and are one half game behind Washington for the final NFC wild-card spot. The Lions' only recent loss was 28-25 to Buffalo on November 24. Jamal Williams leads the league with 14 rushing touchdowns. Carolina Panthers are second in the NFL in terms of points allowed per game.

Carolina Panthers have won three of their last five games thanks to a strong defense. Carolina has played through quarterback issues all season. Sam Darnold has started the last three games since Baker Mayfield was released. D’Onta Foreman has four 100-yard games in a row since becoming a starter in Week 7.

DeShon Elliott and Kayode Awosika are out for the Lions. Frank Ragnow has not practiced this week but is expected to play. Carolina Panthers starting cornerback C.J. Henderson will play after leaving the Pittsburgh game last week early.

Detroit Lions are 7-0 ATS in their last seven games. Carolina Panthers are 3-5-1 AET.