Panthers vs. Lions odds, line, spread: 2022 NFL picks, Week 16 predictions, bets from proven computer model

Detroit Lions are looking to keep their late-season surge alive against the Carolina Panthers. Kickoff is set for 1 p.m. ET. Detroit is a 2.5-point favorite. The Panthers are four games below the .500 mark this season. Carolina won the last meeting 20-0 in 2020. SportsLine's computer model simulates every NFL game 10,000 times and is up more than $7,100 for $100 players on top-rated NFL picks since its inception.

SportsLine's computer model has set its sights on Panthers vs. Lions. The model is using a model that has a very high level of accuracy.

Panthers vs. Lions is a NFL game. The Panthers are favored by 2.5 points.

Carolina Panthers are coming off a loss to Pittsburgh. They had won three of their previous four games despite being underdogs. Carolina has covered the spread in four of its last five games. The Panthers have won seven of the last nine meetings between these teams.

Detroit has won six of its last seven games. The Lions are 7-0 against the spread in their last 7 games, including 20-17 win over the New York Jets last week. Jared Goff has thrown 219 straight passes without an interception. Carolina's quarterback situation is not nearly as favorable as Detroit's.

The model simulates Lions vs. Panthers 10,000 times and it's leaning Under. It also generated a point-spread pick that's hitting in more than 50% of simulations.