Florida vs. Kentucky prediction, odds, line: 2022 college football picks, Week 2 best bets from proven model

No. 12 Florida Gators and No. 20 Kentucky Wildcats will play each other at 7 p.m. ET on Saturday at Ben Hill Griffin Stadium in Gainesville. Florida is favored by 5 points. The over/under is set at 52.5. Kentucky won the last game 20-13. The model at SportsLine simulates every FBS college football game 10,000 times and has returned a profit of almost $3,500 for $100 players on its top-rated collegeFootball picks.

SportsLine's computer model has set its sights on Florida vs. Kentucky and has made its picks and CFB predictions. Florida is a 5-point favorite.

Florida vs. Kentucky is a college football game. Florida is favored by 5 points.

Kentucky beat Miami 37-13 on Saturday. Tayvion Robinson had six catches for 136 yards in his debut. Will Levis' 13 interceptions last year led the SEC. Florida and Kentucky meet in 2022.

Florida beat Utah 29-26 on Saturday. Florida's victory came on a one-yard rush from quarterback Anthony Richardson with 1:29 remaining in the fourth quarter. Utah ran for 230 yards and almost 6.0 yards per carry.

The model simulates Florida vs. Kentucky 10,000 times and it has generated a point-spread pick that is hitting in over 50% of simulations.