Florida vs. USF prediction, odds, line: 2022 college football picks, Week 3 best bets from proven model

Florida Gators host South Florida Bulls at 7:30 p.m. ET on Saturday at Florida Field at Ben Hill Griffin Stadium. Florida is favored by 24.5 points. South FLamont is 1-1 overall and playing in their first road game of the season. The Bulls rebounded from a loss against BYU with a blowout win over Howard last Saturday. SportsLine's computer model simulates every FBS college football game 10,000 times and has returned a profit of almost $3,400 for $100 players on its top-rated college college sports picks.

SportsLine's computer model has set its sights on Florida vs. South Florida and has made its CFB picks and predictions. Florida is a 24-5 favorite.

Florida vs. South Florida is a college football game. Florida has a 24.5-24.50 favorite. The game is expected to be played on September 14th.

Florida came up short against the Kentucky Wildcats on Saturday, falling 26-16. Quarterback Anthony Richardson struggled in the loss. Trevor Etienne and Xzavier Henderson were the only bright spots for the Gators on offense. Florida has one of the worst opponent third down conversion rates in college football, at 46.15 percent.

South Florida beat Howard Bison 42-20 on Saturday. Brian Battie was the offensive standout for the Bulls. Jeff Scott's team has struggled to stop opponents on third down. Florida has been even worse, allowing opponents to convert 53.33 percent of their third-down attempts.

The model simulates Florida vs. South Florida 10,000 times and it has picked Florida to win. The model is leaning Over on the point total and has a point-spread pick that is hitting in nearly 60% of simulations.