Guardians vs. Tigers odds, prediction, line: 2022 MLB picks, Wednesday, July 6 best bets from proven model

Detroit Tigers and Cleveland Guardians play each other on Wednesday at 1:10 p.m. ET at Comerica Park. The Tigers won the first three games of the four-game set. Cleveland has lost five of six games. Caesars Sportsbook lists Cleveland as a -190 favorite on the money line. SportsLine's advanced computer simulation model simulates every MLB game 10,000 times. It is 271-232 on top-rated MLB money-line picks since the start of 2021 season.

Guardians vs. Tigers is a Wednesday, July 6 MLB game. The money line is Guardians -190, Tigers +158. Guardians are 22-20 in day games, while Tigers are 19-22 in games played in the day.

Guardians are 22-20 in day games and Detroit Tigers are 19-22 in the same category.

Cleveland is in a solid position with Shane Bieber on the mound. Bieber is a two-time All-Star and a 2020 AL Cy Young winner. He has a 2.72 ERA over the last three seasons. In 2022, Bieber has 3.16 ERA and he is walking only 2 2 batters per nine innings. Detroit is below the AL average in several key offensive metrics.

Guardians and Tigers are playing on Wednesday. Michael Pineda is scheduled to start for the Tigers. Pino has a 3.62 ERA and a 1.13 WHIP this season. He is pitching well at Comerica Park with a 2.82 ERA in home games.

Guardians vs. Tigers is a 2022 MLB game on Wednesday, July 6. SportsLine's model is leaning under on the total.