Minnesota Twins at Cleveland Guardians odds, picks and predictions

The Minnesota Twins (73-66) and Cleveland Guardians (66-73) meet Wednesday for the finale of their 13-game season series. First pitch from Progressive Field is set for 1:10 p.m. ET (MLB Network). Let’s analyze BetMGM Sportsbook’s lines around the Twins vs. Guardians odds and make our expert MLB picks and predictions for the best bets.

Season series: Tied 6-6

Minnesota won 8-3 as a -110 road favorite to take a 2-0 series lead Tuesday. Minnesota trailed 3-2 heading into the 6th, but scored 6 runs in the 6th and 8th innings to win the game.

The Twins have won back-to-back games and are 6-4 in their last 10 overall. Minnesota is 33-37 on the road. Cleveland is 35-36 at home and has lost 3-straight. The Guardians are 5-5 in their last 10.

Twins at Guardians projected starters

RHP Joe Ryan vs. RHP Gavin Williams

Ryan (10-8, 4.20 ERA) makes his 25th start. He has a 1.12 WHIP, 1.8 BB/9 and 10.9 K/9 in 137 innings.

• Last outing: Win, 6 IP, 1 ER, 3 H, 0 BB, 7 K in a 5-1 road win Friday vs. the Texas Rangers
• Career vs. Cleveland: 3-2, 1.83 ERA (44 1/3 IP, 9 ER), 28 H, 0.74 WHIP, 6.9 K/9 in 7 starts

Williams (1-5, 3.46 ERA) makes his 14th start. The rookie has a 1.28 WHIP, 3.4 BB/9 and 9.4 K/9 in 65 innings.

• Last outing: No-decision, 1 IP, 0 ER, 0 H, 1 BB, 0 K in a 4-2 road loss Aug. 29 vs. Minnesota Twins
• Career vs. Minnesota: 1 IP, 0 ER, 0 H, 1 BB, 0 K in 1 start

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Twins at Guardians odds

BetMGM Sportsbook; access USA TODAY Sports Scores and Sports Betting Odds hub for a full list. Lines last updated at 12:03 a.m. ET.

Twins at Guardians picks and predictions

Prediction

Twins 6, Guardians 5

LEAN TWINS (-135).

These teams have been very evenly matched as a 6-6 season series attests, but the Twins do have a slight edge with the Guardians starting a rookie and this likely being a bullpen game for Cleveland. Neither pitcher is hot, but Ryan is the better SP here.

BET GUARDIANS +1.5 (-155).

I believe the Twins will win as they carry all the momentum, but the Guardians’ home crowd should give them some life and propel them to keep the game close. Of course, it’s understandable if you do not want to pay the juice here.

LEAN OVER 8.5 (-115).

The Over has hit in the 1st 2 games of the series. The Over is also 4-0 in Minnesota’s last 4 games overall and 6-4 in Cleveland’s last 10. The Over is 3-1-1 in Ryan’s last 5 starts, but it’s a lean because the Under is 3-0 in Ryan’s last 3 starts vs. Cleveland.