NFL Upset Picks, Predictions: Top Underdog Picks for Week 10

The New York Jets upset the Buffalo Bills, who had -560 ML odds at onepoint in the week. Seven of the last nine weeks have seen at least one underdog of seven or more points win outright. There are five underdogs with that big of point spreads this week, so bettors will have plenty of opportunities to cash in.

Tom Brady was one drive away from being three games under.500 for the first time in his career. Seattle has allowed 16.5 points per game during a four-game winning streak. Geno Smith is coming off his seventh game this season with two or more touchdown passes. Kenneth Walker III is the Seahawk with 50-plus rushing yards and a rushing touchdown in five consecutive games.

Denver is 7-1 against the spread in its last eight meetings with Tennessee. Denver has a significant scheduling advantage following a bye week. Tennessee played late on Sunday night last week and they were beaten by the Chiefs.

Colts are the only team to have trailed entering the fourth quarter in every game this season. The Raiders have three losses thisseason when leading by 17-plus points. Las Vegas is the lone AFC team without a road win.

NFL Upset Picks, Predictions: Top Underdog Picks for Week 10 were made 11/08/2022 at 5:38 a.m. ET.